GC 靶点信息

GC 分子靶点信息概述

  • 分子名：GC, GC vitamin D binding protein
  • 别名：DBP; VDBP; hDBP
  • 全称：group-specific component (vitamin D binding protein); GC, vitamin D binding protein

GC 分子靶点综述

维生素D结合蛋白(VitaminDBP)也称为gc(组特异性成份)球蛋白，与人血清白蛋白和甲胎蛋白均属于白蛋白基因家族。它具有多种功能，存在于血浆、腹水、脑脊髓液和很多类型细胞的表面。它与维生素D及其代谢产物结合，将它们转运至靶组织。作为Gc蛋白衍生的巨噬细胞活化因子，VitaminDBP可用于癌症治疗，活化巨噬细胞抵抗肿瘤细胞。

GC, GC vitamin D binding protein 分子靶点种属信息

人 Human小鼠 Mouse大鼠 Rat

人 Human GC 分子靶点信息

  • 分子名：GC, GC vitamin D binding protein
  • 别称：
    • DBP
    • DBP-maf
    • DBP/GC
    • epididymis secretory protein Li 51
    • gc protein-derived macrophage activating factor
    • gc-globulin
    • Gc-MAF
    • GcMAF
    • GRD3
    • group-specific component (vitamin D binding protein)
    • HEL-S-51
    • VDB
    • VDBG
    • VDBP
    • vitamin D-binding alpha-globulin
    • vitamin D-binding protein
    • vitamin D-binding protein-macrophage activating factor
  • 基因序列：NCBI_Gene: 2638
  • 蛋白序列：UniProtKB: P02774

人 Human GC靶点分子功能（预测）

Enables actin binding activity and calcidiol binding activity. Predicted to be involved in vitamin transport. Predicted to act upstream of or within vitamin D metabolic process. Located in blood microparticle and extracellular exosome. Implicated in several diseases, including autoimmune disease (multiple); chronic obstructive pulmonary disease; hepatocellular carcinoma; human immunodeficiency virus infectious disease; and rheumatic fever. Biomarker of several diseases, including autoimmune disease (multiple); dengue disease; diabetic retinopathy; hepatic encephalopathy; and sciatic neuropathy.

小鼠 Mouse Gc 分子靶点信息

小鼠 Mouse Gc 靶点分子功能（预测）

Predicted to enable actin binding activity and calcidiol binding activity. Acts upstream of or within vitamin D metabolic process. Predicted to be located in several cellular components, including axon; extracellular space; and perinuclear region of cytoplasm. Predicted to be active in cytoplasm. Is expressed in several structures, including gut; hemolymphoid system gland; liver; male reproductive gland or organ; and trigeminal nerve. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); chronic obstructive pulmonary disease; hepatocellular carcinoma; human immunodeficiency virus infectious disease; and rheumatic fever. Orthologous to human GC (GC vitamin D binding protein).

大鼠 Rat Gc 分子靶点信息

  • 分子名：Gc, GC, vitamin D binding protein
  • 别称：
    • DBP
    • DBP02
    • gc-globulin
    • group specific component
    • group-specific component
    • Group-specific component (vitamin D-binding protein)
    • RATDBP02
    • VDB
    • Vdbp
    • vitamin D-binding protein
  • 基因序列：NCBI_Gene: 24384
  • 蛋白序列：

大鼠 Rat Gc 靶点分子功能（预测）

Enables vitamin D binding activity. Involved in several processes, including female pregnancy; lactation; and response to estradiol. Located in several cellular components, including axon; extracellular space; and perinuclear region of cytoplasm. Biomarker of brain ischemia and hepatocellular carcinoma. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); chronic obstructive pulmonary disease; hepatocellular carcinoma; human immunodeficiency virus infectious disease; and rheumatic fever. Orthologous to human GC (GC vitamin D binding protein).

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