EK121

Human IL-21 ELISA Kit检测试剂盒（酶联免疫吸附法）

¥1,600.00 – ¥2,650.00

分子靶点：IL21, IL-21
种属：人 (Human)
样本类型：血清，血浆，细胞培养上清及其他生物学样本
检测样本体积：血清血浆：50 μL；细胞培养上清：100 μL
灵敏度：11.99 pg/mL
检测范围：62.5 pg/mL - 4000 pg/mL
回收率：87% - 112%

在售SKU:70-EK121-48, 70-EK121-96

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描述

文章目录[隐藏]

分子信息
IL21 分子靶点信息概述
IL21 分子靶点综述
- 人 Human IL21 分子靶点信息
- 人 Human IL21靶点分子功能（预测）

商品名	Human IL-21 ELISA Kit (人白介素21 ELISA 试剂盒)
检测方法	双抗夹心法
精密度	板内变异系数：4.5% - 5.1%；板间变异系数：7.2% - 7.7%
样本类型	血清，血浆，细胞培养上清及其他生物学样本
检测样本体积	血清血浆：50 μL；细胞培养上清：100 μL
灵敏度	11.99 pg/mL
检测范围	62.5 pg/mL - 4000 pg/mL
回收率	87% - 112%
平均回收率	1.02
板式	96孔板，可拆
保存	试剂盒未拆开，4℃保存。已拆开，标准品-20℃保存，其它4℃保存。
运输条件	4℃蓝冰运输
组分	包被抗IL-21单克隆抗体的96孔聚苯乙烯酶标板人IL-21冻干标准品 IL-21检测抗体标准品稀释液辣根过氧化物酶标记的链霉亲和素检测缓冲液(10×) 底物(TMB) 终止液洗液(20×)

检测原理：本试剂盒采用双抗体夹心酶联免疫吸附检测技术。特异性抗人IL-21抗体预包被在高亲和力的酶标板上。酶标板孔中加入标准品、待测样本和生物素化的检测抗体，经过孵育，样本中存在的IL-21与固相抗体和检测抗体结合。洗涤去除未结合的物质后，加入辣根过氧化物酶标记的链霉亲和素(Streptavidin-HRP)。洗涤后，加入显色底物TMB，避光显色。颜色反应的深浅与样本中IL-21的浓度成正比。加入终止液终止反应，在450 nm波长(参考波长570 - 630 nm)测定吸光度值。

Human IL-21 ELISA Kit (人白介素21 ELISA 试剂盒) - 标准曲线 — 标准曲线

分子信息

概述人 IL21, IL-21 靶点信息

IL21 分子靶点信息概述

分子名：IL21, interleukin 21
基因家族：Interleukins
别名：Za11; IL-21

IL21 分子靶点综述

白细胞介素21(IL-21)对免疫细胞具有强烈的调节作用，包括可破坏病毒感染或肿瘤细胞的自然杀伤细胞(NK)和细胞毒性T细胞。该细胞因子可诱导靶细胞分裂/增殖。IL-21表达于人活化的CD4+T细胞，但在其他大多数组织中并没有表达。此外，IL-21在辅助性T细胞亚群Th2和Th17细胞以及滤泡性T细胞中表达上调。而且IL-21还表达于调控这些细胞功能的NKT细胞中。IL-21在免疫炎性疾病中具有病理作用。研究表明存在一个正向自分泌环，可放大并稳定IL-21驱使的、T细胞介导的应答。而且，它还具有抗肿瘤活性，对自身免疫进程具有作用。在临床上，IL-21还可作为潜在的抗肿瘤药物。

人 Human IL21 分子靶点信息

分子名：IL21, interleukin 21
别称：
- CVID11
- IL-21
- interleukin-21
- interleukin-21 isoform
- Za11
基因序列：NCBI_Gene: 59067
蛋白序列：UniProtKB: Q9HBE4

人 Human IL21靶点分子功能（预测）

Enables interleukin-2 receptor binding activity. Involved in several processes, including positive regulation of interleukin-17 production; positive regulation of natural killer cell mediated cytotoxicity; and tyrosine phosphorylation of STAT protein. Acts upstream of or within positive regulation of B cell proliferation; positive regulation of T cell proliferation; and positive regulation of tyrosine phosphorylation of STAT protein. Predicted to be located in extracellular region. Implicated in asthma; common variable immunodeficiency; hepatocellular carcinoma; and systemic lupus erythematosus. Biomarker of several diseases, including anogenital venereal wart; autoimmune disease (multiple); dengue hemorrhagic fever; human immunodeficiency virus infectious disease; and tropical spastic paraparesis.